Gene Spotlight: GSTM1 and Detoxification

A GSTM1 ‘null’ genotype results in a functional loss of this important detox enzyme.

The GSTM1 null genotype refers to a genetic variation in the glutathione S-transferase mu 1 (GSTM1) gene, resulting in the absence or deletion of the GSTM1 enzyme.

Glutathione S-transferases (GSTs) are enzymes involved in the detoxification process by allowing the addition of glutathione (our master antioxidant) to various toxic compounds, making them more water-soluble and easier to excrete from the body.

GSTM1 belongs to the superfamily of GSTs that are phase II antioxidant enzymes and are regulated by Nrf2 (nuclear factor erythroid 2-related factor 2).

Longitudinal data finds GSTM1 null genotypes are associated with an increased risk of toxin accumulation, kidney disease, and even high blood pressure.

Much is due to the increased oxidative stress this loss of GSTM1 results in.

Cruciferous vegetables in general, and broccoli in particular, are rich in glucoraphanin, a precursor of sulforaphane that has been shown to have protective effects against oxidative damage through the activation of Nrf2, effectively bypassing GSTM1.

So if you’re ‘null’ or want to support detox and hype up your body’s antioxidant capacity, eat your cruciferous veg!*

*With sulforaphane activation, it’s important to cut your veg and then let them chill for ~40 minutes for sulforaphane to activate. Sprinkle with ground mustard seed for optimal enhancement.